Why the study?
Does prior atropinization attenuate the acute hemodynamic changes of cardiogenic shock induced by coronary embolization in dogs?
Population
Intact dogs
Comparison
Coronary embolization with lycopodium spore… vs Prior atropinization versus no prior…
Design
Preclinical
Authors
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Vagal pathways may mediate acute hemodynamic deterioration after coronary embolization in dogs; leaves open any role for atropine in human cardiogenic shock.
Does prior atropinization attenuate the acute hemodynamic changes of cardiogenic shock induced by coronary embolization in dogs?
In a canine model, the profound acute hemodynamic deterioration following coronary embolization is partially mediated by vagal pathways, as evidenced by partial blockade with atropine.
Guzmán et al. (1962) studied this question.
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