What question did this study set out to answer?

To determine the physiological effects of localized coronary artery embolization on both embolized and nonembolized coronary vascular beds in an intact animal model.

May 1, 1962Circulation ResearchOpen Access

Intercoronary Reflex

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Population

Intact anesthetized dogs

Design

Preclinical

Authors

SGSantiago GuzmánUniversity of the Philippines System ESEdward W. SwensonUnited States Department of Veterans Affairs MJMalcolm N. JonesUniversity of Southern California

Discussion

Member takes

Implication

Hypothesis-generating for vagally mediated intercoronary reflexes; leaves open any clinical role for atropine in human coronary syndromes.

Key Points

To determine the physiological effects of localized coronary artery embolization on both embolized and nonembolized coronary vascular beds in an intact animal model.
Catheterized the anterior descending and circumflex branches of the left coronary artery via carotid access in intact anesthetized dogs without opening the chest.
Assessed coronary vascular responses before and after embolization using roentgenography and high-speed cinefluorography following radiopaque contrast injection, with and without atropine pretreatment.
Embolization of a single coronary branch produced marked narrowing of the vascular bed, delayed contrast clearance, and contrast reflux into adjacent vessels or the aorta across both embolized and nonembolized regions.
Localized coronary embolization consistently induced generalized left coronary vasoconstriction under experimental conditions.
Pretreatment with atropine substantially prevented the generalized coronary vasoconstrictor response.

Structured PICO

Population

Intact anesthetized dogs

Intervention

Coronary embolization of a branch of the left coronary artery

Outcome

Changes in the coronary vascular bed (size, contrast reflux, and disappearance time) assessed by roentgenography and cinefluorographysurrogate

Coronary embolization in a canine model induces generalized left coronary vasoconstriction that can be prevented by atropine, suggesting a vagally mediated intercoronary reflex.

Cite This Study

Guzmán et al. (1962) studied this question.

synapsesocial.com/papers/6a74698e0081fe7b05dbd262 https://doi.org/10.1161/01.res.10.5.739

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Implication

Hypothesis-generating for vagally mediated intercoronary reflexes; leaves open any clinical role for atropine in human coronary syndromes.