What question did this study set out to answer?

To determine whether the failure of peripheral vascular resistance to increase contributes to sustained hypotension following myocardial infarction induced by coronary artery embolization.

February 1, 1970Circulation ResearchOpen Access

Inhibition of Reflex Vasoconstriction after Experimental Coronary Embolization in the Dog

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Why the study?

Does experimental coronary embolization inhibit reflex vasoconstriction during hypotension in dogs?

Population

Dogs (experimental model)

Comparison

Experimental coronary embolization vs Nonembolized animals with equivalent hypotension…

Design

Preclinical

Authors

DTDaniel B. ToubesUniversity of Iowa MBMichael J. BrodyUniversity of the Sciences

Discussion

Member takes

Implication

Reflex vasoconstriction is inhibited via vagal afferents after embolization in dogs; leaves open relevance to human post-MI hypotension.

Key Points

To determine whether the failure of peripheral vascular resistance to increase contributes to sustained hypotension following myocardial infarction induced by coronary artery embolization.
Measured hindlimb vascular resistance in dogs during sustained severe hypotension following coronary artery embolization in intact, innervated, and denervated autoperfused limbs under constant flow.
Compared vascular responses against control animals experiencing vagal stimulation-induced hypotension and evaluated the effects of bilateral cervical vagotomy after embolization.
Vascular resistance remained unchanged during sustained hypotension after embolization across intact, innervated, and denervated hindlimbs.
Non-embolized dogs demonstrated an immediate, large increase in hindlimb vascular resistance during equivalent hypotension, confirming that post-infarction reflex vasoconstriction was inhibited.
Bilateral cervical vagotomy restored normal reflex vasoconstriction during post-infarction hypotension, indicating the baroreceptor reflex is inhibited by cardiac vagal afferent activation.

Structured PICO

Does experimental coronary embolization inhibit reflex vasoconstriction during hypotension in dogs?

Population

Dogs (experimental model)

Intervention

Experimental coronary embolization

Comparator

Nonembolized animals with equivalent hypotension produced by stimulation of the sectioned vagus nerve

Outcome

Changes in hindlimb vascular resistance during hypotensionsurrogate

Following experimental myocardial infarction, the baroreceptor reflex that normally promotes vasoconstriction during hypotension is inhibited, likely via activation of cardiac vagal afferents.

Cite This Study

Toubes et al. (1970) studied this question.

synapsesocial.com/papers/6a788fbd7d04941475aebdc3 https://doi.org/10.1161/01.res.26.2.211

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Inhibition of Reflex Vasoconstriction after Experimental Coronary Embolization in the Dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Inhibition of Reflex Vasoconstriction after Experimental Coronary Embolization in the Dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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