What is the clinical evidence from this study?

Study design: Other. Population: coronary embolization. Intervention: Coronary embolization with mercury. Primary outcome: renal vascular resistance (mean decrease 28%).

What question did this study set out to answer?

This study aims to investigate the vascular responses in renal and femoral beds following coronary embolization in dogs.

March 1, 1975Cardiovascular Research

The response of the renal and femoral vascular beds to coronary embolization in the dog

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Key result

Coronary embolization with mercury in dogs induced a prompt decrease in renal vascular resistance (mean decrease 28 ± 4% at 2 min) despite systemic and femoral vasoconstriction.

Why the study?

Does coronary embolization alter renal and femoral vascular resistance in anaesthetized dogs?

Population

Anaesthetized dogs

Design

Preclinical

Follow-up

Up to 90 minutes

Authors

RFRaul E. FalicovChrist Hospital CMCallaway MillsHammersmith Hospital IGI. T. GabeMidhurst Community Hospital

Discussion

Member takes

Implication

Caution against extrapolating canine embolization responses to patients; leaves open human cardiorenal reflexes in acute ischemia.

Key Points

This study aims to investigate the vascular responses in renal and femoral beds following coronary embolization in dogs.
Anaesthetized dogs were subjected to coronary embolization using mercury.
Vascular resistance changes were measured in renal, femoral, and systemic beds after embolization.
The effect of an exogenous vasoconstrictor (1-noradrenaline) on renal response was evaluated post-embolization.
Femoral and systemic vascular resistance increased after embolization, indicating systemic vasoconstriction.
Renal vascular resistance decreased by 28 ± 4% at 2 minutes post-embolization, with sustained effects for at least 90 minutes in some cases.
The renal blood flow increased, showing a significant vasodilator response despite the systemic reaction.

Structured PICO

Does coronary embolization alter renal and femoral vascular resistance in anaesthetized dogs?

Population

Anaesthetized dogs subjected to coronary embolization with mercury to study renal, femoral, and systemic vascular responses.

Intervention

Coronary embolization with mercury

Outcome

Renal, femoral, and systemic vascular resistance and blood flowsurrogate

Main Result

Effect estimate: mean decrease 28%

Coronary embolization in dogs induces systemic and femoral vasoconstriction but paradoxical early and sustained renal vasodilatation.

Cite This Study

Falicov et al. (1975) studied coronary embolization. Coronary embolization with mercury was evaluated on renal vascular resistance (mean decrease 28%). Coronary embolization with mercury in dogs induced a prompt decrease in renal vascular resistance (mean decrease 28 ± 4% at 2 min) despite systemic and femoral vasoconstriction.

synapsesocial.com/papers/6a61cd1cf2fc5dc74fc1f5d4 https://doi.org/10.1093/cvr/9.2.151

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The response of the renal and femoral vascular beds to coronary embolization in the dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

The response of the renal and femoral vascular beds to coronary embolization in the dog

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider