Key result
Residual TR ≤1+ after intervention is linked to ~33 mL RV EDV reduction.
Why the study?
Right ventricular reverse remodelling is linked to improved survival after interventional treatment for severe tricuspid regurgitation and right-sided heart failure, but the role of residual tricuspid regurgitation on right ventricular reverse remodelling remained unclear.
Does optimal procedural success (residual TR ≤1+) following transcatheter tricuspid valve intervention improve right ventricular reverse remodelling in patients with severe tricuspid regurgitation and right-sided heart failure?
Cohort (n=253)
Blinded imaging analysis
Yes
Does optimal procedural success (residual TR ≤1+) following transcatheter tricuspid valve intervention improve right ventricular reverse remodelling in patients with severe tricuspid regurgitation and right-sided heart failure?
Optimal procedural reduction of tricuspid regurgitation (to mild or none) during transcatheter intervention is associated with significantly greater right ventricular reverse remodelling than moderate or severe residual regurgitation.
Residual TR ≤1+ may enhance RV remodeling after TTVI; hypothesis-generating and needs randomized confirmation before practice change.
AIMS: Right ventricular reverse remodelling (RVRR) is linked to improved survival in patients with severe tricuspid regurgitation (TR) and right-sided heart failure who underwent interventional treatment. However, the role of residual TR on RVRR remains unclear. In this analysis the impact of residual TR on RVRR after interventional TR treatment, which was validated by two independent cohorts at four sites using echocardiography or cardiac magnetic resonance (CMR) imaging, was investigated. METHODS AND RESULTS: Overall, 253 patients who were treated for severe TR and right-sided heart failure using different treatment modalities (tricuspid transcatheter edge-to-edge repair [T-TEER], transcatheter tricuspid valve annuloplasty, orthotopic transcatheter TV replacement [TTVR], heterotopic TTVR) were included. Three-dimensional echocardiographic and CMR-based assessment of RVRR and clinical evaluation of decongestion or exercise capacity were performed at baseline and 30 days after the procedure. Mortality was analysed at 1 year after transcatheter tricuspid valve intervention (TTVI). In patients with residual TR ≤1+ pronounced reduction of right ventricular end-diastolic and end-systolic volumes was observed. In patients with residual TR ≥2+ the effect of RVRR gradually decreased with higher residual TR reinforcing the relevance of optimal procedural results for RVRR. These findings were validated in two independent cohorts. In contrast to RVRR, residual TR ≤1+ and 2+ were associated with similar 1-year survival. RVRR was only observed after T-TEER or orthotopic TTVR, but not after heterotopic TTVR as expected. However, all three treatment modalities were accompanied by significant decongestion and functional improvement at 30-day follow-up. CONCLUSIONS: In patients with severe TR and right-sided heart failure undergoing TTVI, superior procedural results were associated with more pronounced RVRR.
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Weckbach et al. (2024) conducted a cohort in Severe tricuspid regurgitation and right-sided heart failure (n=253). Residual TR ≤1+ after transcatheter tricuspid valve intervention vs. Residual TR ≥2+ after transcatheter tricuspid valve intervention was evaluated on Change in right ventricular end-diastolic volume (RV EDV) at 30 days (Reduction of 33 ml (-18%) from baseline, p=<0.0001). In patients with severe tricuspid regurgitation undergoing interventional treatment, achieving a residual TR ≤1+ was associated with pronounced right ventricular reverse remodeling (-33 ml RV EDV, p<0.0001).
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