Key result
An optimized risk score predicted 6-month mortality in rural AMI patients with an AUC of 0.81 in the validation cohort, superior to the GRACE risk score (AUC 0.75; p < .05).
Why the study?
Risk stratification of patients with acute myocardial infarction is of great clinical significance, motivating an optimized risk score to predict short-term death in rural Chinese patients.
Does an optimized risk score improve prediction of short-term death compared to the GRACE risk score in rural Chinese patients with acute myocardial infarction?
Population
6581 AMI patients in rural China (5539 derivation, 1042 validation)
Comparison
Optimized risk score vs GRACE risk score
Design
Derivation and validation cohort study
Follow-up
6-month
Authors
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May aid short-term mortality prediction in rural Chinese AMI patients; leaves open external validation before clinical use.
Cohort (n=6,581)
Does an optimized risk score improve prediction of short-term death compared to the GRACE risk score in rural Chinese patients with acute myocardial infarction?
Effect estimate: AUC 0.81
p-value: p=< .05
A newly developed optimized risk score using six clinical variables provides superior prediction of 6-month mortality compared to the GRACE score in rural Chinese patients with AMI.
Wang et al. (2021) conducted a cohort in acute myocardial infarction (n=6,581). Optimized risk score vs. GRACE risk score was evaluated on Short-term (6-month) death (AUC 0.81, p=< .05). An optimized risk score predicted 6-month mortality in rural AMI patients with an AUC of 0.81 in the validation cohort, superior to the GRACE risk score (AUC 0.75; p < .05).
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