What question did this study set out to answer?

The aim is to assess the relationships between SET morphology, immune microenvironment characteristics, and progression-free survival in advanced-stage HGSC.

July 21, 2026CancersOpen Access

Prognostic Value of Morphological Characteristics and Immune Microenvironment in High-Grade Serous Cancer (HGSC)

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Authors

DGDanijel Antonio GrubisicUniversity of Split BMBranka Petrić MišeUniversity of Split TČToni ČeprnjaKlinički Bolnički Centar Split

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Implication

Retrospective cohort analysis investigates immune characteristics and progression-free survival in high-grade serous cancer, suggesting implications for immunotherapy.

Key Points

The aim is to assess the relationships between SET morphology, immune microenvironment characteristics, and progression-free survival in advanced-stage HGSC.
Analyzed a retrospective cohort of 305 patients with FIGO stage III–IV HGSC treated from 1996 to 2021.
Conducted histopathological assessments, including evaluation of SET morphology, immune cell infiltration, and CD8/PD-L1 expression.
Evaluated associations using χ2, logistic regression, Kaplan–Meier analysis, log-rank testing, and Cox proportional hazards regression.
SET morphology correlated with higher levels of sTIL and itTIL, CD8+ T-cell infiltration, and PD-L1 expression (all p < 0.05).
Age > 55 years was linked to a 50% increased risk of disease progression (HR = 1.5, 95% CI: 1.1–2.1; p = 0.012).
Higher intraepithelial TIL levels (>10%) were associated with improved PFS (HR = 2.1, 95% CI: 1.0–4.4; p = 0.045).

Cite This Study

Grubisic et al. (2026) studied this question.

synapsesocial.com/papers/6a5f0bea86a4235cc161987a https://doi.org/10.3390/cancers18142327

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Implication

Retrospective cohort analysis investigates immune characteristics and progression-free survival in high-grade serous cancer, suggesting implications for immunotherapy.

Prognostic Value of Morphological Characteristics and Immune Microenvironment in High-Grade Serous Cancer (HGSC)

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Implication

Key Points

Cite This Study

Prognostic Value of Morphological Characteristics and Immune Microenvironment in High-Grade Serous Cancer (HGSC)

Discussion

Member takes

Implication

Key Points

Cite This Study

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