Key result
Dialysis with a high-calcium dialysate (1.75 mmol/l) significantly increased aortic and brachial pulse wave velocity in haemodialysis patients, whereas low-calcium dialysate did not.
Why the study?
Does dialysis with high-calcium dialysate increase pulse wave velocity in haemodialysis patients compared to low-calcium dialysate?
Does dialysis with high-calcium dialysate increase pulse wave velocity in haemodialysis patients compared to low-calcium dialysate?
In haemodialysis patients, an increase in serum ionized calcium from high-calcium dialysate decreases arterial compliance, while waste-product retention itself does not appear responsible for increased pulse wave velocity.
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High-calcium dialysate may acutely increase arterial stiffness in hemodialysis; leaves open optimal concentration for cardiovascular outcomes.
Marchais et al. (1989) studied Uraemia / Haemodialysis (n=26). High-calcium dialysate vs. Low-calcium dialysate (1.50 mmol/l) was evaluated on Aortic and brachial pulse wave velocity. Dialysis with a high-calcium dialysate (1.75 mmol/l) significantly increased aortic and brachial pulse wave velocity in haemodialysis patients, whereas low-calcium dialysate did not.
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