Key result
Metabolic syndrome was associated with a higher median Gensini score, indicating greater coronary artery severity, in patients with acute myocardial infarction compared to those without (p=0.002).
Why the study?
Metabolic syndrome is frequently observed in acute myocardial infarction, but research assessing its impact on coronary artery severity in these patients is limited.
Does metabolic syndrome increase angiographic coronary artery severity in patients with acute myocardial infarction?
Observational (n=199)
Does metabolic syndrome increase angiographic coronary artery severity in patients with acute myocardial infarction?
Metabolic syndrome, particularly elevated waist circumference and blood glucose, is associated with greater angiographic coronary artery severity (higher Gensini score) in patients presenting with acute myocardial infarction.
Metabolic syndrome flags greater coronary severity in acute MI; extends angiographic associations to this high-risk cohort.
INTRODUCTION: Metabolic syndrome (MetS) has been frequently observed in patients with acute myocardial infarction (AMI). However, there is limited research assessing the impact of metabolic syndrome on coronary artery severity in patients with acute myocardial infarction. METHODS: We analyzed 199 patients with AMI who underwent invasive coronary angiography. This study aimed to determine the impact of MetS, MetS score and its components on coronary artery severity. RESULTS: The study comprised 199 eligible patients, with an average age of 64.5±11.3 years. Among the entire cohort, 136 patients (68.3%) were diagnosed with MetS. The MetS 3 subgroup with three components exhibited the highest percentage at 29.2%. The proportion of one-vessel, two-vessel, three-vessel, multi-vessel disease, or left main disease did not differ between the MetS and non-MetS groups (p>0.05). Our study revealed that the MetS group had a higher median Gensini score compared to the non-MetS group (p=0.002). Furthermore, the Gensini score was significantly correlated with the MetS score (Spearman correlation 0.2, p<0.05). Among metabolic syndrome components, elevated waist circumference and elevated blood glucose were associated with the Gensini score. CONCLUSIONS: Our study revealed that MetS, MetS score and two components of MetS, elevated waist circumference and elevated blood glucose, were associated with the severity of angiographic coronary artery in patients with AMI.
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Tran et al. (2024) conducted an observational in Acute myocardial infarction (n=199). Metabolic syndrome vs. No metabolic syndrome was evaluated on Coronary artery severity (Gensini score) (p=0.002). Metabolic syndrome was associated with a higher median Gensini score, indicating greater coronary artery severity, in patients with acute myocardial infarction compared to those without (p=0.002).
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