Key result
Metabolic syndrome in acute coronary syndrome patients was associated with significantly higher angiographic severity, including higher Gensini scores (p=0.0007) and more three-vessel disease.
Why the study?
Does metabolic syndrome increase angiographic severity in patients with acute coronary syndrome?
Observational (n=100)
No
Does metabolic syndrome increase angiographic severity in patients with acute coronary syndrome?
p-value: p=0.0007
In patients with acute coronary syndrome, the presence of metabolic syndrome is associated with significantly higher angiographic severity and more extensive coronary artery disease.
Coronary artery disease (CAD) is a major health problem around the world. Acute coronary syndrome (ACS) is a serious and life threatening presentation of CAD. Metabolic syndrome (MetS) is a major risk factor for CAD. To study the impact of MetS on angiographic severity in Egyptian ACS patients. The study included 100 patients admitted to coronary care unit of Zagazig University Hospital by ACS, among them 50 patients had Mets. All patients had undergone history taking and clinical examination, ECG, echocardiography, laboratory tests, and coronary angiography with measuring of Gensini score. Patients with metabolic syndrome were significantly younger (p = 0.003). Body mass index, waist circumference, systolic, and diastolic blood pressures, fasting blood glucose, hemoglobin A1c, and serum triglycerides were significantly higher, and HDL-cholesterol was significantly lower in metabolic syndrome patients (p < 0.00001 for each). Incidence of left main coronary artery disease and three-vessel disease were significantly higher in metabolic syndrome patients (p = 0.027, and 0.0211 respectively). Gensini score was significantly higher in metabolic syndrome patients (p = 0.0007). There was a significant positive correlation between Gensini score and waist circumference (r = 0.345, p = 0.0004), hemoglobin A1c (r = 0.297, p = 0.0027), and systolic blood pressure (r = 0.253, p = 0.012). Acute coronary syndrome patients when associated with metabolic syndrome tend to have more extensive coronary artery disease.
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Mustafa et al. (2016) conducted an observational in Acute coronary syndrome (n=100). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Angiographic severity (Gensini score) (p=0.0007). Metabolic syndrome in acute coronary syndrome patients was associated with significantly higher angiographic severity, including higher Gensini scores (p=0.0007) and more three-vessel disease.
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