Key result
Development of systemic inflammatory response syndrome within 72 hours after TAVI was an independent predictor of 24-month all-cause mortality (HR 3.7; 95% CI 1.5-9; P=0.004).
Why the study?
SIRS can affect mortality after TAVI up to 12 months, but its prevalence and impact on all-cause mortality up to 24 months remained to be evaluated.
Does the development of systemic inflammatory response syndrome (SIRS) after TAVI predict mortality in patients with symptomatic severe aortic stenosis?
Cohort (n=132)
Does the development of systemic inflammatory response syndrome (SIRS) after TAVI predict mortality in patients with symptomatic severe aortic stenosis?
Hazard Ratio: 3.7 (95% CI 1.5–9)
p-value: p=0.004
The development of systemic inflammatory response syndrome within 72 hours after TAVI is a strong independent predictor of both short-term and 24-month all-cause mortality.
May enhance post-TAVI risk stratification; leaves open whether anti-inflammatory strategies alter outcomes.
AIMS: Systemic inflammatory response syndrome (SIRS) could affect mortality after transcatheter aortic valve implantation (TAVI) up to 12 months of follow-up. The aim of this study was to evaluate the prevalence of SIRS after TAVI and its impact on all-cause mortality up to 24 months follow-up. METHODS: We retrospectively enrolled 132 patients with symptomatic severe aortic stenosis undergoing TAVI. SIRS development during the first 72 h after the intervention was evaluated. Other postoperative complications were defined according to the Valve Academic Research Consortium 2 (VARC2). All patients underwent follow-up at 30 days and 24 months. Endpoints were 30-days and 24-months mortality. RESULTS: Post-TAVI SIRS developed in 27 patients (20%). At 30-day follow-up, all-cause death occurred in 10 (8%) patients and SIRS occurred more frequently in patients with adverse short-term outcome (60 vs. 17%; P = 0.001). Twenty-four months all-cause death occurred in 25 (19%) patients. SIRS resulted as an independent predictor of long-term outcome [hazard ratio 3.7; 95% confidence interval (95% CI) 1.5-9; P = 0.004], along with major vascular complications (hazard ratio 4; 95% CI 1.6-9.9; P = 0.003), relevant bleedings (hazard ratio 6.4; 95% CI 1.5-28; P = 0.013) and baseline pulmonary hypertension (hazard ratio 2.4; 95% CI 1.05-5.6; P = 0.039). CONCLUSION: Postoperative SIRS was more frequent in patients who died at 30 days follow-up. Moreover, SIRS resulted as a predictor of 24-month mortality along with vascular complications, relevant bleedings and baseline pulmonary hypertension.
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Monosilio et al. (2022) conducted a cohort in symptomatic severe aortic stenosis (n=132). Systemic inflammatory response syndrome (SIRS) vs. No SIRS was evaluated on 24-month all-cause mortality (HR 3.7, 95% CI 1.5-9, p=0.004). Development of systemic inflammatory response syndrome within 72 hours after TAVI was an independent predictor of 24-month all-cause mortality (HR 3.7; 95% CI 1.5-9; P=0.004).
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