Key result
Increased aortic stiffness predicts future cardiovascular events and improves risk reclassification in patients at intermediate risk.
Vascular stiffness, particularly aortic stiffness measured by pulse wave velocity, is a reliable biomarker of vascular aging that predicts future cardiovascular events and improves risk reclassification.
Aortic stiffness may refine CV risk prediction beyond standard factors; leaves open routine clinical adoption pending prospective validation.
Increasing evidence points out at vascular stiffness (and in particular aortic stiffness measured by pulse wave velocity) as a reliable biomarker of vascular aging, able to integrate in a single measure the overall burden of cardiovascular (CV) risk factors on the vasculature over time; furthermore, it may be per se a mechanism of disease, by inducing microcirculatory damage and favoring CV events. Increased aortic stiffness has been shown to predict future CV events and improve risk reclassification in those at intermediate risk. However, several questions in this field are still open, limiting the wide use of these tools in the clinical practice. This article will review the basic aspects of physiology of large artery stiffness, as well as current evidence about its possible clinical applications.
No takes yet. Share an insight, caveat, or question.
Boutouyrie et al. (2018) conducted a review in Cardiovascular risk. Vascular stiffness measurements was evaluated. Increased aortic stiffness predicts future cardiovascular events and improves risk reclassification in patients at intermediate risk.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: