Key result
A sequence-independent metagenomics approach successfully identified a single viral agent in each of five previously untypable samples, including potentially new orthoreovirus and orbivirus species.
Population
5 infectious samples inoculated into suckling mice
Design
Preclinical
Authors
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Simple metagenomic sequencing identifies known and divergent viruses from untyped isolates; leaves open routine surveillance adoption pending validation.
A simple, inexpensive, and rapid metagenomics approach is effective for identifying known and highly divergent new viruses in homogenized tissues of acutely infected mice.
Victoria et al. (2008) studied Unknown viral infections (n=5). Sequence-independent amplification and shotgun sequencing was evaluated on Identification of viral agents. A sequence-independent metagenomics approach successfully identified a single viral agent in each of five previously untypable samples, including potentially new orthoreovirus and orbivirus species.
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