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October 31, 2017European Heart Journal - Cardiovascular ImagingOpen Access

Comparison of MOLLI, shMOLLLI, and SASHA in discrimination between health and disease and relationship with histologically derived collagen volume fraction

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Key result

Native T1 mapping with MOLLI and shMOLLI demonstrated excellent discriminatory accuracy between health and disease (AUC 0.94 and 0.87) and correlated significantly with collagen volume fraction.

Why the study?

Do different T1 mapping sequences (MOLLI, shMOLLI, SASHA) differ in their ability to discriminate between health and disease and correlate with histological myocardial fibrosis?

Population

83 individuals, including patients with non-ischaemic dilated cardiomyopathy, aortic stenosis, and healthy…

Comparison

T1 mapping using MOdified Look-Locker Inversion… vs SAturation recovery single-SHot Acquisition T1…

Design

Cross-sectional

Authors

NCNicholas ChildUniversity of AucklandGSGonca SunaUniversity of ZurichDDDarius DabirGoethe University Frankfurt

Discussion

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Implication

Supports diagnostic potential of MOLLI T1 mapping; hypothesis-generating and requires prospective validation before practice change.

Study Design

Type

Cross-Sectional (n=83)

Structured PICO

Do different T1 mapping sequences (MOLLI, shMOLLI, SASHA) differ in their ability to discriminate between health and disease and correlate with histological myocardial fibrosis?

P
Population
83 individuals, comprising 32 with non-ischaemic dilated cardiomyopathy, 25 with aortic stenosis, and 26 healthy controls, evaluated for bioequivalence of T1 mapping sequences.
E
Exposure
T1 mapping using MOdified Look-Locker Inversion recovery (MOLLI) and Shortened MOdified Look-Locker Inversion recovery (shMOLLI) sequences
C
Comparator
SAturation recovery single-SHot Acquisition (SASHA) T1 mapping sequence (intra-individual sequence comparison)
O
Outcome
Discriminatory accuracy between health and disease, and relationship with histologically derived collagen volume fraction (CVF)surrogate

Main Result

Effect estimate: AUC 0.94 for MOLLI (95% CI 0.88-0.99)

MOLLI and shMOLLI T1 mapping sequences outperform SASHA in discriminating myocardial disease from health and correlating with histological diffuse fibrosis.

Cite This Study

Child et al. (2017) conducted a cross-sectional in Diffuse myocardial fibrosis (n=83). T1 mapping sequences (MOLLI, shMOLLI, SASHA) vs. Healthy controls was evaluated on Discriminatory accuracy between health and disease (AUC 0.94 for MOLLI, 95% CI 0.88-0.99). Native T1 mapping with MOLLI and shMOLLI demonstrated excellent discriminatory accuracy between health and disease (AUC 0.94 and 0.87) and correlated significantly with collagen volume fraction.

synapsesocial.com/papers/6a61ecc2ce9bb37a6d7d9b39https://doi.org/10.1093/ehjci/jex309

Topics

Cardiac MRICardiomyopathyHFrEF treatmentHeart failure
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessment of Diffuse Myocardial Fibrosis by Using MR Imaging in Asymptomatic Patients with Aortic Stenosis2014 · 145 citations
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