Key result
Positive IgG from mothers with CHB children significantly inhibited both I(Ca.T) and I(Ca.L) and induced sinus bradycardia in young rabbit SA node cells, compared to normal IgG.
Why the study?
Does positive IgG from mothers with CHB children inhibit pacemaker currents and induce sinus bradycardia in rabbit SA node cells?
Does positive IgG from mothers with CHB children inhibit pacemaker currents and induce sinus bradycardia in rabbit SA node cells?
Maternal antibodies associated with congenital heart block induce sinus bradycardia by inhibiting L- and T-type calcium currents in SA node cells.
No takes yet. Share an insight, caveat, or question.
May implicate maternal IgG in fetal sinus bradycardia; hypothesis-generating for CHB mechanisms and requires human validation.
Hu et al. (2004) studied Congenital heart block. Antibodies (positive IgG) from mothers with CHB children vs. Normal IgG from mothers with healthy children was evaluated on Effects on L- (I(Ca.L)) and T- (I(Ca.T)) type Ca2+, delayed rectifier K+ (I(K)), hyperpolarization-activated (I(f)) currents, and action potentials. Positive IgG from mothers with CHB children significantly inhibited both I(Ca.T) and I(Ca.L) and induced sinus bradycardia in young rabbit SA node cells, compared to normal IgG.
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