Key result
In dyslipidemic subjects, symptomatic coronary artery disease was associated with elevated inflammatory markers and carotid IMT, but not with further endothelial dysfunction.
Why the study?
Is the presence of symptomatic coronary artery disease associated with worse endothelial function, inflammation, and carotid IMT in dyslipidemic patients?
Observational (n=102)
Is the presence of symptomatic coronary artery disease associated with worse endothelial function, inflammation, and carotid IMT in dyslipidemic patients?
In dyslipidemic patients, symptomatic CAD is associated with increased inflammation and structural vascular changes (IMT) rather than further impairment of endothelial function.
Inflammation markers may aid CAD risk stratification in dyslipidemia; leaves open endothelial function's independent prognostic role.
INTRODUCTION: Endothelial dysfunction and inflammation play a key role in the development of atherosclerosis. The present study evaluated endothelial function, inflammatory parameters, and carotid intima-media thickness (IMT) in dyslipidemic patients with or without coronary artery disease (CAD). METHODS: Metabolic profile and inflammatory parameters were determined in dyslipidemic patients with (+CAD, n = 33) and without (-CAD, n = 69) symptomatic CAD. Endothelial function was evaluated by flow mediated dilatation (FMD) and plasma concentration of nitrites and nitrates. Carotid IMT was measured by ultrasound. RESULTS: No significant differences were observed in anthropometric hemodynamic or metabolic parameters between the groups. After adjusting by age and medication usage, some inflammatory markers were significantly higher in +CAD; however no significant differences in FMD or plasma levels of nitrites were observed. CONCLUSIONS: In subjects with dyslipidemia, the presence of CAD is associated with an elevation of certain inflammatory markers and carotid IMT but not with further endothelial dysfunction.
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Rueda‐Clausen et al. (2009) conducted an observational in Dyslipidemia with or without coronary artery disease (n=102). Symptomatic coronary artery disease vs. Absence of symptomatic coronary artery disease was evaluated on Endothelial function, inflammatory parameters, and carotid intima-media thickness. In dyslipidemic subjects, symptomatic coronary artery disease was associated with elevated inflammatory markers and carotid IMT, but not with further endothelial dysfunction.
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