Key result
A 60-minute bout of moderate-intensity exercise significantly attenuated the decline in flow-mediated dilation following high-fat meals in adolescent boys (6% and 10% reductions) compared to control (32% and 24% reductions) (P=0.002).
Why the study?
Does moderate-intensity exercise prevent postprandial endothelial dysfunction following high-fat meals in adolescent boys?
RCT (n=13)
Open-label
Counter-balanced cross-over
No
Does moderate-intensity exercise prevent postprandial endothelial dysfunction following high-fat meals in adolescent boys?
p-value: p=0.002
Moderate-intensity exercise attenuates the acute endothelial dysfunction induced by high-fat meals in adolescent boys.
May support exercise around high-fat meals to limit acute endothelial stress in boys; leaves open long-term outcome benefits.
The ingestion of high-fat meals induces a state of endothelial dysfunction in adults. This dysfunction is attenuated by prior exercise. The response of young people to these nutritional and physiological stressors has not been established. Thus, the purpose of the present study was to investigate if a bout of moderate-intensity exercise influenced endothelial function (as indicated by flow-mediated dilation (FMD)) following the ingestion of a high-fat breakfast and lunch in adolescent boys (aged 12·6-14·3 years). Two, 2 d main trials (control and exercise) were completed by thirteen adolescent boys in a counter-balanced, cross-over design. Participants were inactive on day 1 of the control trial, but completed 60 min of walking at 60 % peak oxygen uptake in the exercise trial. On day 2, endothelial function was assessed via FMD prior to, and following, ingestion of a high-fat breakfast and lunch. There was no difference in fasting FMD between the control and exercise trial (P= 0·449). In the control trial, FMD was reduced by 32 % following consumption of the high-fat breakfast and by 24 % following lunch. In the exercise trial, the corresponding reductions were 6 and 10 %, respectively (main effect trial, P= 0·002). These results demonstrate that moderate-intensity exercise can attenuate the decline in FMD seen following the consumption of high-fat meals in adolescent boys.
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Sedgwick et al. (2012) conducted an RCT in Healthy (n=13). Moderate-intensity exercise vs. Physically inactive control was evaluated on Flow-mediated dilation (FMD) following ingestion of a high-fat breakfast and lunch (p=0.002). A 60-minute bout of moderate-intensity exercise significantly attenuated the decline in flow-mediated dilation following high-fat meals in adolescent boys (6% and 10% reductions) compared to control (32% and 24% reductions) (P=0.002).
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