May 1, 1999Current Opinion in Cardiology
An overview of tumor necrosis factor α and the failing human heart
Key result
Cytokines, such as tumor necrosis factor alpha, may represent a class of biologically active molecules responsible for the development and progression of heart failure.
Population
Heart failure
Design
Review
Authors
Discussion
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Implication
Leaves open cytokine inhibition as heart failure therapy; hypothesis-generating pending randomized trials.
Key Points
- This article aims to explore the role of cytokines, particularly tumor necrosis factor alpha, in heart failure.
- Reviewed recent clinical and experimental studies on cytokines in heart failure.
- Analyzed the impact of tumor necrosis factor alpha and neurohormones on heart disease.
- Cytokines are implicated in the progression of heart failure, similar to neurohormones.
- Tumor necrosis factor alpha is identified as a significant biologically active molecule associated with heart failure.
Structured PICO
P
Population
Heart failure
This review highlights the potential pathophysiological role of cytokines, specifically TNF-alpha, in the development and progression of heart failure.
Cite This Study
Torre‐Amione et al. (1999) conducted a review in Heart failure. Tumor necrosis factor alpha (cytokines) was evaluated on Development and progression of heart failure. Cytokines, such as tumor necrosis factor alpha, may represent a class of biologically active molecules responsible for the development and progression of heart failure.