Why the study?
Does antihypertensive medication use impact residual cardiovascular mortality risk in elderly individuals aged 60-89 years?
Population
n=26,133 residents aged 60-89 years from seven Japanese general populations, cross-classified by age category.
Comparison
Antihypertensive medication at baseline. vs No antihypertensive medication at baseline.
Design
Cohort
Follow-up
median 12.7 years
Key result
Antihypertensive medication use was associated with increased cardiovascular mortality compared to no treatment in young-old (HR 1.30; 95% CI 1.16-1.46) and old-old (HR 1.35; 95% CI 1.16-1.56) adults.
Authors
Loading...
May reflect confounding by indication; leaves open causal effects of antihypertensives on mortality in older adults.
Cohort (n=26,133)
Yes
Does antihypertensive medication use impact residual cardiovascular mortality risk in elderly individuals aged 60-89 years?
Hazard Ratio: 1.3 (95% CI 1.16–1.46)
Elderly individuals receiving antihypertensive treatment have a higher residual risk of cardiovascular mortality compared to untreated individuals, indicating a need for continued close monitoring.
Asayama et al. (2017) conducted a cohort in Cardiovascular risk (n=26,133). Antihypertensive medication vs. Untreated participants was evaluated on Cardiovascular mortality (HR 1.30, 95% CI 1.16-1.46). Antihypertensive medication use was associated with increased cardiovascular mortality compared to no treatment in young-old (HR 1.30; 95% CI 1.16-1.46) and old-old (HR 1.35; 95% CI 1.16-1.56) adults.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: