August 1, 2013EuroIntervention
Rationale and design of a large registry on renal denervation: the Global SYMPLICITY registry
Key result
The Global SYMPLICITY registry was designed to evaluate the safety and efficacy of the Symplicity renal denervation system in real-world uncontrolled hypertensive patients.
Why the study?
Does renal artery denervation using the Symplicity system safely lower blood pressure in real-world uncontrolled hypertensive patients?
Population
Real-world uncontrolled hypertensive patients, initially focusing on severe resistant hypertension, and…
Design
Cohort
Authors
Discussion
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Implication
Real-world registry data inform renal denervation safety in hypertension; extends trials but leaves open randomized confirmation.
Study Design
Type
Observational
Multicenter
Yes
Structured PICO
Does renal artery denervation using the Symplicity system safely lower blood pressure in real-world uncontrolled hypertensive patients?
P
Population
Real-world uncontrolled hypertensive patients, initially focusing on severe resistant hypertension (systolic BP >160 mmHg), and expanding to subjects with a wider range of baseline blood pressure and coexisting comorbidities.
E
Exposure
Renal artery denervation using the Symplicity system (radiofrequency ablation of renal artery nerves).
O
Outcome
Safety and efficacy (blood pressure lowering).surrogate
The Global SYMPLICITY registry is designed to evaluate the real-world safety and efficacy of renal denervation in a broad population of uncontrolled hypertensive patients.
Cite This Study
Böhm et al. (2013) conducted an observational in Hypertension. Symplicity renal denervation system was evaluated on Safety and efficacy. The Global SYMPLICITY registry was designed to evaluate the safety and efficacy of the Symplicity renal denervation system in real-world uncontrolled hypertensive patients.