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November 1, 2019International Journal of Cardiology HypertensionOpen Access

Recent multicenter sham-controlled studies reported positive placebo-subtracted results with established blood pressure reductions measured both in the office and by ambulatory monitoring.

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Why the study?

Following neutral results from the sham-controlled SYMPLICITY HTN-3 trial, substantial basic and clinical research was conducted to re-evaluate renal denervation for uncontrolled hypertension.

Does renal denervation reduce blood pressure in patients with uncontrolled hypertension?

Population

Patients with uncontrolled hypertension across multiple studies

Comparison

Renal denervation vs sham control

Design

Review of 5 sham-controlled studies and registries

Authors

VPVasilios PapademetriouKSKonstantinos StavropoulosKIKostas Imprialos

Discussion

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Overview

May support renewed RDN interest with refined techniques; leaves open efficacy confirmation in sham-controlled trials.

Structured PICO

Does renal denervation reduce blood pressure in patients with uncontrolled hypertension?

P
Population
Patients with uncontrolled hypertension
I
Intervention
Renal denervation (using single tip or multi-electrode radiofrequency catheters, or focused ultrasound)
C
Comparator
Sham control
O
Outcome
Reduction in office and 24 h ambulatory blood pressuresurrogate

Recent sham-controlled studies have established the efficacy and safety of renal denervation for reducing blood pressure in patients with uncontrolled hypertension.

Cite This Study

Papademetriou et al. (2019) studied this question.

synapsesocial.com/papers/6a727e93f44fa9f079dff5f4https://doi.org/10.1016/j.ijchy.2019.100022
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