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January 1, 2022Clinical HypertensionOpen Access

Effectiveness of renal denervation in the treatment of hypertension: a literature review

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Why the study?

Preclinical studies demonstrated an antihypertensive effect of renal denervation, but reports from clinical trials have been mixed.

Does catheter-based renal denervation reduce blood pressure in patients with hypertension?

Design

Literature review

Authors

RSRiya Tejas ShahBWBrian Wang

Discussion

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Overview

Mixed renal denervation trial results leave open its role in resistant hypertension; additional RCTs required before practice change.

Structured PICO

Does catheter-based renal denervation reduce blood pressure in patients with hypertension?

P
Population
Patients with hypertension (including resistant hypertension) and preclinical animal models (e.g., spontaneously hypertensive rats, obese hypertensive dogs, ovine models)
I
Intervention
Catheter-based renal denervation (radiofrequency, ultrasound, or alcohol-mediated)
C
Comparator
Sham procedure or standard antihypertensive medical therapy (as evaluated in the reviewed studies)
O
Outcome
Reduction in office and ambulatory blood pressuresurrogate

This review highlights that contemporary, rigorously designed sham-controlled trials support the efficacy of catheter-based renal denervation in reducing blood pressure, positioning it as a potential adjunctive treatment for hypertension.

Cite This Study

Shah et al. (2022) studied this question.

synapsesocial.com/papers/6a7cfb39a0d4e77c65aeb77fhttps://doi.org/10.1186/s40885-022-00194-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal denervation for the treatment of resistant hypertension: review and clinical perspective2015 · 51 citations
  2. 2Renal Denervation: Past, Present, and Future2016 · 3 citations
  3. 3Renal denervation: recent developments in clinical and preclinical research2023 · 4 citations
  4. 4Renal denervation: from establishing effectiveness to measuring success2026
  5. 5Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis2014 · 8 citations