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May 1, 2016Cardiovascular Innovations and ApplicationsOpen Access

Renal Denervation: Past, Present, and Future

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Why the study?

Does percutaneous renal denervation lower blood pressure in patients with resistant hypertension compared to medical therapy?

Population

Patients with resistant hypertension, as well as those with systolic and diastolic heart failure, metabolic…

Comparison

Percutaneous renal denervation vs Medical therapy and/or sham control

Design

Review

Authors

NPNegiin PourafsharGeorgetown UniversityAKAshkan KarimiTU WienRAR. David AndersonInterventional Cardiology

Discussion

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Overview

SYMPLICITY HTN-3 cautions against routine renal denervation in resistant hypertension; leaves open optimized trial designs for future evaluation.

Structured PICO

Does percutaneous renal denervation lower blood pressure in patients with resistant hypertension compared to medical therapy?

P
Population
Patients with resistant hypertension, as well as those with systolic and diastolic heart failure, metabolic syndrome, arrhythmia, and obstructive sleep apnea
I
Intervention
Percutaneous renal denervation (e.g., SYMPLICITY radiofrequency catheter system)
C
Comparator
Medical therapy and/or sham control
O
Outcome
Blood pressure lowering effectsurrogate

This review summarizes the evolution of renal denervation trials, highlighting the negative results of SYMPLICITY HTN-3 and the subsequent redesign of clinical trials like SPYRAL HTN.

Cite This Study

Pourafshar et al. (2016) studied this question.

synapsesocial.com/papers/6a87f055729e8aa7bb582636https://doi.org/10.15212/cvia.2016.0016
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal denervation: What happened, and why?2017 · 6 citations
  2. 2Renal denervation for the treatment of resistant hypertension: review and clinical perspective2015 · 51 citations
  3. 3Renal Denervation: Past, Present, and Future2015 · 5 citations
  4. 4Effectiveness of renal denervation in the treatment of hypertension: a literature review2022 · 7 citations
  5. 5SYMPLICITY HTN 3: The death knell for renal denervation in hypertension?2014 · 17 citations