Key result
Renal denervation failed to reduce office systolic blood pressure compared to a sham procedure at 6 months in patients with resistant hypertension.
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This editorial discusses the implications of the SYMPLICITY HTN-3 trial's failure to meet efficacy endpoints for renal denervation in resistant hypertension.
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Shishehbor et al. (2017) conducted a review in Resistant hypertension (n=535). Renal denervation vs. Sham procedure was evaluated on Reduction in office systolic blood pressure at 6 months (MD 2.39 mm Hg, p=Not statistically significant). Renal denervation failed to reduce office systolic blood pressure compared to a sham procedure at 6 months in patients with resistant hypertension.
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