Key result
Renal denervation failed to significantly reduce office systolic blood pressure compared to a sham procedure at 6 months (mean reduction of 14.13 mm Hg vs 11.74 mm Hg, difference of 2.39 mm Hg) in patients with resistant hypertension.
Population
Patients with resistant hypertension
Design
Editorial
Authors
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Does not support renal denervation for resistant hypertension; leaves open questions on patient selection and technique in future trials.
Mean Difference: 2.39
Absolute Event Rate: 14.13% vs 11.74%
p-value: p=Not statistically significant
This editorial discusses the implications of the SYMPLICITY HTN-3 trial's failure to meet efficacy endpoints for renal denervation in resistant hypertension.
Shishehbor et al. (2017) conducted a review in Resistant hypertension (n=535). Renal denervation vs. Sham procedure was evaluated on Reduction in office systolic blood pressure at 6 months (MD 2.39 mm Hg, p=Not statistically significant). Renal denervation failed to significantly reduce office systolic blood pressure compared to a sham procedure at 6 months (mean reduction of 14.13 mm Hg vs 11.74 mm Hg, difference of 2.39 mm Hg) in patients with resistant hypertension.
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