Why the study?
Does renal denervation reduce blood pressure in patients with hypertension?
Does renal denervation reduce blood pressure in patients with hypertension?
This review summarizes the evolving evidence for renal denervation in hypertension, contrasting early setbacks with recent positive trial data.
Renal denervation remains investigational; leaves open questions on durability, selection, and generalizability after mixed trial results.
Renal denervation is a relatively recent concept whose initial promising results suffered a setback following the SYMPLICITY 3 trial, which did not show a significant blood pressure-lowering effect in comparison to sham. In this review article, we begin with the history including the physiological basis behind the concept of renal denervation. Furthermore, we review the literature in support of renal denervation, including the recently published SPYRAL HTN-OFF MED, which demonstrated significant blood pressure reduction in the absence of antihypertensive medication. We further touch upon the potential pitfalls and possible future directions of renal denervation.
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Padmanabhan et al. (2018) studied this question.
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