Key result
Renal denervation demonstrated a 5-10 mmHg incremental reduction in ambulatory systolic blood pressure compared to sham control in patients with mild-to-moderate hypertension.
Why the study?
Following the failure of the first sham-controlled study to achieve its primary endpoint, lessons learned and new anatomical knowledge were applied in newer sham-controlled trials evaluating renal denervation.
Does renal sympathetic denervation reduce ambulatory systolic blood pressure compared to sham control in patients with hypertension?
Comparison
Renal denervation vs sham-control
Design
Review
Authors
Loading...
May support RDN consideration in hypertension; leaves open durability, selection, and outcome data.
Does renal sympathetic denervation reduce ambulatory systolic blood pressure compared to sham control in patients with hypertension?
Effect estimate: 5-10 mmHg incremental reduction
Recent sham-controlled trials provide proof of principle that renal denervation lowers ambulatory systolic blood pressure by 5-10 mmHg in patients with mild-to-moderate hypertension.
Dasgupta et al. (2019) conducted a review in Hypertension. Renal denervation vs. Sham-control was evaluated on Ambulatory systolic blood pressure (5-10 mmHg incremental reduction). Renal denervation demonstrated a 5-10 mmHg incremental reduction in ambulatory systolic blood pressure compared to sham control in patients with mild-to-moderate hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: