Key result
Thrombus aspiration before primary percutaneous coronary intervention significantly reduced 30-day all-cause mortality to 3.0% compared to 7.0% with PPCI alone in frail elderly patients with STEMI.
Why the study?
Despite PPCI being the preferred therapy in older frail adults with STEMI, cardiovascular re-hospitalization rates remain high, prompting investigation into whether thrombus aspiration before PPCI reduces mortality and rehospitalizations.
Does thrombus aspiration before PPCI reduce mortality and rehospitalizations in frail elderly patients with STEMI?
Population
389 consecutive frail patients aged ≥ 65 years with first STEMI
Comparison
TA + PPCI vs PPCI alone
Design
Cohort study
Follow-up
1-month
Authors
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TA + PPCI was associated with lower 1-month mortality in frail STEMI patients; hypothesis-generating and should not change practice pending randomized trials.
Observational (n=389)
No
Does thrombus aspiration before PPCI reduce mortality and rehospitalizations in frail elderly patients with STEMI?
Absolute Event Rate: 3% vs 7%
p-value: p=0.036
Mone et al. (2021) conducted an observational in ST-segment elevation myocardial infarction (STEMI) with frailty (n=389). Thrombus aspiration (TA) plus PPCI vs. PPCI alone was evaluated on All-cause mortality at 30 days (p=0.036). Thrombus aspiration before primary percutaneous coronary intervention significantly reduced 30-day all-cause mortality to 3.0% compared to 7.0% with PPCI alone in frail elderly patients with STEMI.