Key result
Turpentine-induced acute inflammation increased plasma TPO concentrations and hepatic TPO mRNA levels in wild-type mice, whereas no increase occurred in IL-6 knockout mice.
Why the study?
Does IL-6 mediate the increase in TPO production during acute inflammation in mice?
Population
Wild-type and IL-6 knockout mice
Comparison
Subcutaneous injection of turpentine oil to… vs Wild-type vs IL-6 knockout mice
Design
Preclinical
Follow-up
72 h
Authors
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IL-6 may mediate TPO upregulation during murine acute inflammation; leaves open relevance to human thrombopoiesis.
Does IL-6 mediate the increase in TPO production during acute inflammation in mice?
The study demonstrates that TPO acts as an acute-phase protein, with its synthesis in the liver being induced by IL-6 during acute inflammation.
Burmester et al. (2005) studied Acute inflammation. Turpentine oil injection vs. IL-6 knockout mice was evaluated on Plasma TPO concentrations and hepatic TPO mRNA levels. Turpentine-induced acute inflammation increased plasma TPO concentrations and hepatic TPO mRNA levels in wild-type mice, whereas no increase occurred in IL-6 knockout mice.
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