What is the clinical evidence from this study?

Study design: Other. Population: Type 2 diabetes (ZDF rat model) (n=44). Intervention: Aerobic exercise training vs. Sedentary control. Primary outcome: R wave amplitude change.

September 22, 2010Cardiovascular DiabetologyOpen Access

Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat

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Key result

Seven weeks of aerobic exercise training in Zucker Diabetic Fatty rats ameliorated diabetes-induced R wave amplitude augmentation but did not attenuate QTc interval prolongation or restore decreased heart rate variability.

Why the study?

Does aerobic exercise training attenuate diabetes-induced ECG changes in male Zucker Diabetic Fatty rats?

Population

Male Zucker Diabetic Fatty (ZDF) (obese fa/fa) and control Zucker (lean fa/+) rats

Comparison

7 weeks of treadmill training (aerobic exercise) vs Sedentary control and sedentary diabetic rats

Design

Preclinical

Follow-up

7 weeks

Authors

LVLisa VanHooseLocal Initiatives Support Corporation YSYoussef Sawers RLRajprasad LoganathanJohns Hopkins University

Discussion

Member takes

Implication

Exercise selectively corrects R-wave changes in diabetic rats; leaves open translation to QTc/HRV benefits or human practice.

Structured PICO

Does aerobic exercise training attenuate diabetes-induced ECG changes in male Zucker Diabetic Fatty rats?

Population

44 male Zucker Diabetic Fatty and lean control rats, aged 11 weeks, were studied to assess the impact of 7 weeks of aerobic exercise training on diabetes-induced electrocardiographic changes.

Intervention

7 weeks of treadmill training (aerobic exercise)

Comparator

Sedentary control (SC) and sedentary diabetic (SD) rats

Outcome

ECG parameters (R wave amplitudes, heart rate variability, QT intervals, and QTc intervals)surrogate

In a rat model of type 2 diabetes, 7 weeks of aerobic exercise training corrected diabetes-induced R wave amplitude changes but did not improve QT/QTc prolongation or heart rate variability.

Limitations

Did not measure autonomic function directly
Unable to use echocardiography to correlate ECG findings with left ventricular mass
Mode and duration of exercise might not have been sufficient for QTc interval adaptation
Animals were relatively young and in the latter stages of their growth phase, complicating heart size normalization

Cite This Study

VanHoose et al. (2010) studied Type 2 diabetes (ZDF rat model) (n=44). Aerobic exercise training vs. Sedentary control was evaluated on R wave amplitude change. Seven weeks of aerobic exercise training in Zucker Diabetic Fatty rats ameliorated diabetes-induced R wave amplitude augmentation but did not attenuate QTc interval prolongation or restore decreased heart rate variability.

synapsesocial.com/papers/6a62cfda4f5ef41b946a717d https://doi.org/10.1186/1475-2840-9-56

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Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Electrocardiographic changes with the onset of diabetes and the impact of aerobic exercise training in the Zucker Diabetic Fatty (ZDF) rat

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider