Key result
Insulin-dependent diabetic patients with abnormal heart rate reactions to tilt showed impaired noradrenaline increments during exercise compared to controls (12.38 vs 18.74 nmol/l; P<0.01).
Why the study?
Do insulin-dependent diabetic patients with abnormal heart rate reactions to tilt have impaired plasma catecholamine responses to exercise?
Population
24 insulin-dependent diabetic (IDDM) patients and 18 non-diabetic controls
Comparison
Standardized bicycle exercise test vs Non-diabetic controls
Design
Cross-sectional
Authors
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Suggests early sympathetic impairment in diabetics with tilt abnormalities; hypothesis-generating and requires prospective validation before clinical use.
Observational (n=42)
Do insulin-dependent diabetic patients with abnormal heart rate reactions to tilt have impaired plasma catecholamine responses to exercise?
Absolute Event Rate: 12.38% vs 18.74%
p-value: p=<0.01
Insulin-dependent diabetic patients with abnormal heart rate reactions to tilt exhibit impaired catecholamine responses to exercise, even in the absence of signs of parasympathetic neuropathy.
Bergström et al. (1989) conducted an observational in Insulin-dependent diabetes mellitus (n=42). Insulin-dependent diabetes with abnormal heart rate reactions to tilt vs. Non-diabetic controls was evaluated on Increment in noradrenaline during exercise (80% of maximal working capacity) (p=<0.01). Insulin-dependent diabetic patients with abnormal heart rate reactions to tilt showed impaired noradrenaline increments during exercise compared to controls (12.38 vs 18.74 nmol/l; P<0.01).
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