Key result
A 90-degree tilt in male patients with type I diabetes revealed that a late diastolic blood pressure fall was associated with a significantly lower increase in plasma noradrenaline (55% vs 163%, p<0.005).
Why the study?
Does a 90 degrees tilt test reveal impaired sympatho-adrenal reactions in male patients with type I diabetes?
Population
13 male patients with type I diabetes
Design
Cross-sectional
Follow-up
8 minutes
Authors
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Diastolic BP fall on tilt may indicate sympathetic denervation in type 1 diabetes; cross-sectional data leave open prospective validation.
Observational (n=13)
Does a 90 degrees tilt test reveal impaired sympatho-adrenal reactions in male patients with type I diabetes?
Absolute Event Rate: 55% vs 163%
p-value: p=<0.005
An abnormal immediate heart rate acceleration to tilt is associated with an impaired sympatho-adrenal reaction, and even a minor diastolic blood pressure fall indicates peripheral sympathetic denervation in type I diabetes.
Sundkvist et al. (1984) conducted an observational in Type I diabetes (n=13). 90 degrees and 2 sec tilt vs. Patients without late diastolic blood pressure fall was evaluated on Increase in plasma noradrenaline (PNA) 1-8 min after tilt (p=<0.005). A 90-degree tilt in male patients with type I diabetes revealed that a late diastolic blood pressure fall was associated with a significantly lower increase in plasma noradrenaline (55% vs 163%, p<0.005).
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