Key result
Extracellular divalent and trivalent cations produced voltage-dependent and voltage-independent open channel block of the sodium current in canine cardiac Purkinje cells with varying affinities.
Extracellular divalent and trivalent cations block the cardiac sodium current in canine Purkinje cells via distinct voltage-dependent and voltage-independent mechanisms depending on the cation group.
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Does not alter clinical practice; extends mechanistic insight into cardiac sodium channel blockade by cations.
Sheets et al. (1992) studied Canine cardiac Purkinje cells. Extracellular divalent and trivalent cations vs. Absence of cations was evaluated on Block of sodium ionic current (INa). Extracellular divalent and trivalent cations produced voltage-dependent and voltage-independent open channel block of the sodium current in canine cardiac Purkinje cells with varying affinities.
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