Key result
Bilateral renal denervation prevented the hemorrhage-induced increase in the 0.3-Hz oscillation in blood pressure, indicating these oscillations are primarily mediated by renal sympathetic activity.
Population
Conscious rabbits
Comparison
Bilateral renal denervation vs Intact animals (control group)
Design
Preclinical
Follow-up
20 min
Authors
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Renal SNA may drive Mayer waves in models; leaves open its clinical relevance in human BP control.
Renal sympathetic nerve activity is the primary mediator of the 0.3-Hz slow oscillation in arterial pressure during hemorrhage in rabbits.
Malpas et al. (2000) studied Hemorrhage. Bilateral renal denervation vs. Intact animals was evaluated on Power of 0.3-Hz oscillation in blood pressure during hemorrhage. Bilateral renal denervation prevented the hemorrhage-induced increase in the 0.3-Hz oscillation in blood pressure, indicating these oscillations are primarily mediated by renal sympathetic activity.
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