Key result
Superimposing 0.1-Hz blood pressure oscillations onto reduced renal perfusion pressure blunted hypertension, doubled renal sodium elimination, and transiently stimulated NO liberation in beagles.
RCT (n=7)
randomly assigned
0.1-Hz blood pressure oscillations enhance sodium and water excretion and attenuate the acute development of renovascular hypertension in a canine model.
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0.1-Hz RPP oscillations may attenuate renal hypertension via endothelial NO; leaves open relevance to human BP regulation.
Nafz et al. (2000) conducted an RCT in renal hypertension (n=7). 0.1-Hz blood pressure oscillations vs. Reduced renal perfusion pressure without oscillations was evaluated on Systemic blood pressure, renal excretory function, and plasma renin activity. Superimposing 0.1-Hz blood pressure oscillations onto reduced renal perfusion pressure blunted hypertension, doubled renal sodium elimination, and transiently stimulated NO liberation in beagles.
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