Key result
In isolated rat hearts, mannitol and glucose reduced the incidence of reperfusion-induced sustained ventricular fibrillation from 93% to as low as 7% depending on the concentration and timing.
Why the study?
Do mannitol and glucose reduce reperfusion-induced ventricular fibrillation in isolated rat hearts?
Population
Isolated rat hearts subjected to regional ischemia (10 min) and reperfusion (3 min) (n = 15/group)
Comparison
Mannitol with or without glucose, or glucose… vs Control
Design
Preclinical
Follow-up
3 minutes (reperfusion phase)
Authors
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Requires clinical trials to assess mannitol for reperfusion arrhythmias; hypothesis-generating from rat heart data.
Do mannitol and glucose reduce reperfusion-induced ventricular fibrillation in isolated rat hearts?
Mannitol and glucose synergistically protect against reperfusion-induced ventricular fibrillation in isolated rat hearts, suggesting complex metabolic mechanisms of antiarrhythmic protection rather than simple osmotic or free-radical scavenging effects.
Bernier et al. (1988) studied Reperfusion-induced arrhythmias. Mannitol and/or glucose vs. Control was evaluated on Reperfusion-induced sustained ventricular fibrillation (VF). In isolated rat hearts, mannitol and glucose reduced the incidence of reperfusion-induced sustained ventricular fibrillation from 93% to as low as 7% depending on the concentration and timing.
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