Key points are not available for this paper at this time.
The data in these figures were all derived from the same series of nine large experiments performed over a 2-year period (1998)(1999)(2000) (see Supplementary Table Practically, and for ethical reasons, it was not possible to compare all the groups within any individual experiment and thus, to compare various strains of mice, data were pooled from separate experiments and some cohorts of mice were used in more than one figure. Importantly, the preparation of carcinogen used in these experiments was the same, prepared several weeks before any of the experiments began, and the reproducibility between experiments was high.
Mark J. Smyth (Tue,) studied this question.