Key result
Older age (≥70 years) was associated with a significantly lower warfarin dose (2.2 mg/day) compared to younger patients (2.9 mg/day) despite similar plasma prothrombin concentrations.
Why the study?
Does age affect the required warfarin dosage and plasma prothrombin concentration in patients receiving anticoagulant therapy?
Cross-Sectional (n=227)
Does age affect the required warfarin dosage and plasma prothrombin concentration in patients receiving anticoagulant therapy?
Elderly patients require a significantly lower daily dose of warfarin than younger patients to achieve similar plasma prothrombin concentrations and coagulation parameters.
No age difference in prothrombin levels on or off warfarin; leaves open whether age-specific monitoring adjustments are warranted.
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Iwahashi et al. (2001) conducted a cross-sectional in Warfarin anticoagulant therapy (n=227). Older age (≥70 years) vs. Younger age was evaluated on Warfarin dose (mg/day) (R 0.221, p=0.0154). Older age (≥70 years) was associated with a significantly lower warfarin dose (2.2 mg/day) compared to younger patients (2.9 mg/day) despite similar plasma prothrombin concentrations.
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