Key result
Major congenital heart disease was identified in 7.0% of fetuses with increased nuchal translucency, with the frequency rising from 1.9% at NT 2.5-3.5 mm to 27.7% at NT ≥6.5 mm.
Population
967 fetuses referred from January 1998 until May 2007 with an increased nuchal translucency at 11-14 weeks…
Design
Cohort
Authors
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Supports fetal echocardiography referral for increased NT; leaves open optimal thresholds for routine screening.
Observational (n=967)
No
Increased nuchal translucency in the first trimester is associated with a variety of major congenital heart defects, with the risk increasing significantly as NT thickness increases.
Clur et al. (2008) conducted an observational in Congenital heart disease (n=967). Increased nuchal translucency was evaluated on Major congenital heart disease. Major congenital heart disease was identified in 7.0% of fetuses with increased nuchal translucency, with the frequency rising from 1.9% at NT 2.5-3.5 mm to 27.7% at NT ≥6.5 mm.
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