Why the study?
Does nuchal translucency measurement accurately diagnose major congenital heart defects in fetuses with normal karyotype?
Population
20 studies pooling 205,232 fetuses (537 cases with major CHDs) with normal karyotype.
Design
Meta-analysis
Authors
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Modest sensitivity limits NT >95th centile as a standalone screen for major CHDs; extends evidence supporting integrated markers and echocardiography.
Does nuchal translucency measurement accurately diagnose major congenital heart defects in fetuses with normal karyotype?
Nuchal translucency >95th centile identifies approximately 44% of chromosomally normal fetuses with major congenital heart defects, though with high study heterogeneity.
Sotiriadis et al. (2013) studied this question.
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