Key result
First-trimester nuchal translucency measurement >99th percentile had a sensitivity of 15% and a positive likelihood ratio of 33 for detecting major congenital heart defects in low-risk pregnancies.
Why the study?
Does nuchal translucency measurement in the first trimester predict congenital heart defects in low-risk pregnancies?
Population
4,181 pregnant women without known a priori risk factors in the Netherlands with available pregnancy outcome…
Design
Cohort
Authors
Loading...
Supports selective fetal echocardiography referral; leaves open whether nuchal translucency screening alters CHD detection in low-risk pregnancies.
Cohort (n=4,181)
Yes
Does nuchal translucency measurement in the first trimester predict congenital heart defects in low-risk pregnancies?
Increased nuchal translucency in low-risk pregnancies is associated with major cardiac defects but lacks sufficient sensitivity to serve as a standalone screening tool.
Müller et al. (2007) conducted a cohort in Congenital heart defects (n=4,181). Nuchal translucency (NT) measurement vs. Normal NT measurement was evaluated on Congenital heart defects (CHD). First-trimester nuchal translucency measurement >99th percentile had a sensitivity of 15% and a positive likelihood ratio of 33 for detecting major congenital heart defects in low-risk pregnancies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: