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December 1, 1993Cardiovascular Research

Mitochondrial metabolism and substrate competition in the aging Fischer rat heart

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Key result

In old rat hearts, the suppression of glucose oxidation by fatty acids seen in adult rat hearts is absent, consistent with decreased oxidation of palmitoylcarnitine with senescence.

Population

Mature (8 to 15 months of age) and old (28 to 30 months) Fischer 344 rats

Comparison

Perfusion with 10 mM glucose or glucose plus 1… vs Mature vs old rats, and glucose alone vs glucose…

Design

Preclinical

Authors

JMJ. B. McmillinGTGeorge E. TaffetHeart Failure & TransplantHTHeinrich TaegtmeyerThe University of Texas Health Science Center at Houston

Discussion

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Implication

Hypothesis-generating for age-related cardiac metabolism; leaves open translation to human therapies or practice changes.

Structured PICO

P
Population
Mature (8 to 15 months) and old (28 to 30 months) Fischer 344 rats used to examine mitochondrial oxidative metabolism of long chain fatty acids.
E
Exposure
Perfusion with 10 mM glucose or glucose plus 1 mM oleic acid (2% bovine serum albumin)
C
Comparator
Mature vs old rats, and glucose alone vs glucose + oleic acid
O
Outcome
Mitochondrial oxidative metabolism of long chain fatty acids, glucose uptake, and generation of pressure-volume worksurrogate

Aging in rat hearts is associated with decreased mitochondrial oxidation of fatty acids and a loss of the normal suppression of glucose oxidation by fatty acids.

Cite This Study

Mcmillin et al. (1993) studied Aging heart. Aging (Old vs Mature) vs. Mature rats was evaluated on Glucose utilisation and mitochondrial respiratory function. In old rat hearts, the suppression of glucose oxidation by fatty acids seen in adult rat hearts is absent, consistent with decreased oxidation of palmitoylcarnitine with senescence.

synapsesocial.com/papers/6a63776b84b804377828ba68https://doi.org/10.1093/cvr/27.12.2222
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Also Consider

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  1. 1Cardiomyocyte mitochondrial respiration and microviscosity in rats of different ages in heart failure2023
  2. 2Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice2010 · 67 citations
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  5. 5Respiration in isolated cardiomyocytes and microviscosity of their membranes in rats of different ages with heart failure2023 · 3 citations