Key result
Virulent human rotavirus inoculation caused diarrhea, viral shedding, and viremia in 100% of gnotobiotic pigs, whereas attenuated strains caused asymptomatic shedding without viremia.
Virulent human rotavirus causes transient viremia and upper respiratory tract infection in addition to gastrointestinal infection in a gnotobiotic pig model.
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May inform preclinical rotavirus vaccine strain selection; leaves open translation to human infants.
Azevedo et al. (2005) studied Rotavirus infection. Attenuated and virulent human rotavirus (HRV) vs. Nonreplicating rotavirus-like particles or mock inoculation was evaluated on Viremia and nasal and rectal virus shedding. Virulent human rotavirus inoculation caused diarrhea, viral shedding, and viremia in 100% of gnotobiotic pigs, whereas attenuated strains caused asymptomatic shedding without viremia.
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