What is the clinical evidence from this study?

Study design: Other. Population: Experimental cardiac failure (n=40). Intervention: Doxorubicin injection or coronary ligation vs. Controls. Primary outcome: Ejection fraction (p=<0.001).

What question did this study set out to answer?

To compare haemodynamic performance in vivo and in vitro in experimental cardiac failure models and validate echocardiography for assessing left ventricular dysfunction.

June 1, 1996Cardiovascular ResearchOpen Access

Comparison of in vivo and in vitro haemodynamic function in experimental heart failure: use of echocardiography

Q: What are the key findings of this study?

In experimental rabbit models, mean ejection fractions were significantly lower in doxorubicin-treated (0.45) and coronary ligation (0.42) groups compared to controls (0.65, P<0.001).

Q: What question did this study set out to answer?

To compare haemodynamic performance in vivo and in vitro in experimental cardiac failure models and validate echocardiography for assessing left ventricular dysfunction.

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Key result

In experimental rabbit models, mean ejection fractions were significantly lower in doxorubicin-treated (0.45) and coronary ligation (0.42) groups compared to controls (0.65, P<0.001).

Why the study?

Does echocardiography accurately reflect in vivo and in vitro haemodynamic function in experimental rabbit models of heart failure?

Population

40 rabbits, including experimental cardiac failure models induced by doxorubicin injection or coronary…

Comparison

Echocardiography for non-invasive assessment of… vs In vitro haemodynamic function and in vivo…

Design

Preclinical

Follow-up

8 weeks (for doxorubicin induction)

Authors

MPMaurice PyeBelfast Health and Social Care Trust MBMarjorie BlackUniversity of Glasgow SCStuart M. CobbeElectrophysiology

Discussion

Member takes

Implication

Rabbit models of doxorubicin and ligation reduce EF; extends preclinical HF tools but leaves open human translation.

Key Points

To compare haemodynamic performance in vivo and in vitro in experimental cardiac failure models and validate echocardiography for assessing left ventricular dysfunction.
Cardiac failure induced by doxorubicin injection or coronary ligation in rabbit models (n = 28 total with 12 controls).
Echocardiography assessed left ventricular diastolic dimension and ejection fraction in vivo.
Thermodilution cardiac output was measured in vivo and in vitro under various conditions.
Mean ejection fractions in doxorubicin (0.45) and ligation (0.42) groups were significantly lower than controls (0.65, P < 0.001).
Basal and peak cardiac outputs were lower in pathological groups compared to controls, revealing variability in function.
Ejection fraction correlated significantly with all indices of haemodynamic function both in vivo and in vitro.

Structured PICO

Does echocardiography accurately reflect in vivo and in vitro haemodynamic function in experimental rabbit models of heart failure?

Population

40 rabbits with experimental cardiac failure induced by doxorubicin or coronary ligation, and controls, assessed for haemodynamic function.

Intervention

Echocardiography for non-invasive assessment of left ventricular dysfunction (ejection fraction)

Comparator

In vitro haemodynamic function (working heart mode) and in vivo thermodilution cardiac output

Outcome

Correlation between in vivo echocardiographic ejection fraction and in vivo/in vitro haemodynamic functionsurrogate

Main Result

Absolute Event Rate: 0.45% vs 0.65%

p-value: p=<0.001

Echocardiography provides a valid non-invasive assessment of global cardiac dysfunction that correlates well with invasive haemodynamic parameters in experimental rabbit models of heart failure.

Cite This Study

Pye et al. (1996) studied Experimental cardiac failure (n=40). Doxorubicin injection or coronary ligation vs. Controls was evaluated on Ejection fraction (p=<0.001). In experimental rabbit models, mean ejection fractions were significantly lower in doxorubicin-treated (0.45) and coronary ligation (0.42) groups compared to controls (0.65, P<0.001).

synapsesocial.com/papers/6a63c99e8553b4339ab36062 https://doi.org/10.1016/s0008-6363(96)00051-x

Topics

Echocardiography Heart failure HFrEF treatment

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Comparison of in vivo and in vitro haemodynamic function in experimental heart failure: use of echocardiography

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Topics

Comparison of in vivo and in vitro haemodynamic function in experimental heart failure: use of echocardiography

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider