Key result
Angiotensin peptides Ang-(1-7), Ang-(1-9), and Ang-(3-7) intensified serum starvation-induced cell cycle arrest at the G0/G1 phase in OVPA8 high-grade serous ovarian cancer cells.
Why the study?
A local renin-angiotensin system exists in the ovary and changes in its components are seen in ovarian cancer, but the effects of specific angiotensin peptides in high-grade serous ovarian carcinoma remained to be examined.
Do angiotensin peptides affect the proliferation and motility of high-grade serous ovarian cancer cells under serum starvation conditions?
Do angiotensin peptides affect the proliferation and motility of high-grade serous ovarian cancer cells under serum starvation conditions?
Angiotensin peptides modulate the adaptation of ovarian cancer cells to nutrient deprivation by influencing cell cycle arrest and motility.
No takes yet. Share an insight, caveat, or question.
May alter HGSOC cell proliferation and motility via local RAS; leaves open therapeutic targeting pending in vivo and clinical studies.
Domińska et al. (2021) studied High-grade serous ovarian carcinoma (HGSOC). Angiotensin peptides (Ang-(1-7), Ang-(1-9), and Ang-(3-7)) was evaluated on Proliferation and motility of the OVPA8 cell line. Angiotensin peptides Ang-(1-7), Ang-(1-9), and Ang-(3-7) intensified serum starvation-induced cell cycle arrest at the G0/G1 phase in OVPA8 high-grade serous ovarian cancer cells.
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