Key result
Decreased heart rate variability (SDNN < 70 milliseconds) in patients with cancer was independently associated with shorter survival (HR 1.9; 95% CI 1.4-2.5).
Why the study?
Does decreased heart rate variability reduce survival time in patients with cancer?
Population
651 patients with cancer who had undergone ambulatory electrocardiogram monitoring for 20 to 24 hours
Comparison
Decreased heart rate variability vs Normal or higher heart rate variability
Design
Cohort
Authors
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May aid cancer prognostication; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=651)
Does decreased heart rate variability reduce survival time in patients with cancer?
Hazard Ratio: 1.9 (95% CI 1.4–2.5)
p-value: p=<0.0001
Decreased heart rate variability (SDNN < 70 ms) is an independent prognostic marker for shorter survival in patients with cancer.
Guo et al. (2015) conducted a cohort in Cancer (n=651). Decreased heart rate variability (SDNN < 70 milliseconds) vs. SDNN ≥ 70 milliseconds was evaluated on Survival (HR 1.9, 95% CI 1.4-2.5, p=<0.0001). Decreased heart rate variability (SDNN < 70 milliseconds) in patients with cancer was independently associated with shorter survival (HR 1.9; 95% CI 1.4-2.5).
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