Key result
Prolonged in vitro exposure of rat aorta to the alpha-adrenergic agonist phenylephrine led to enhanced release of endothelium-derived relaxing factor (EDRF) compared with controls.
Population
Rings of rat aorta
Comparison
In vitro exposure to phenylephrine for 6 hours vs Control aortic rings
Design
Preclinical
Follow-up
6 hours
Authors
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Endothelial-dependent alpha-adrenergic desensitization in rat aorta cautions against direct clinical extrapolation; leaves open in vivo relevance and EDRF mechanisms.
Prolonged exposure to alpha-adrenergic agonists induces enhanced release of endothelium-derived relaxing factor (EDRF) in rat aorta, indicating a vascular adaptation mechanism.
Hu et al. (1994) studied this question. Phenylephrine (PE) vs. Controls was evaluated on Release of endothelium-derived relaxing factor (EDRF). Prolonged in vitro exposure of rat aorta to the alpha-adrenergic agonist phenylephrine led to enhanced release of endothelium-derived relaxing factor (EDRF) compared with controls.
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