Key result
Discontinuing unnecessary diuretic therapy (placebo) in the elderly significantly improved metabolic parameters and resulted in only 2 cases of CHF compared to 6 cases with continued therapy.
Why the study?
Does discontinuing unnecessary chronic diuretic therapy using placebo compared to active continuation affect the occurrence of CHF, hypertension, or metabolic parameters in elderly patients?
RCT (n=77)
Double-blind
Stratified for prior hypertension or congestive heart failure
Does discontinuing unnecessary chronic diuretic therapy using placebo compared to active continuation affect the occurrence of CHF, hypertension, or metabolic parameters in elderly patients?
Discontinuing chronic diuretic therapy in elderly patients without a clear indication is safe and improves metabolic parameters without increasing the risk of heart failure or hypertension.
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Supports deprescribing unnecessary chronic diuretics in elderly patients; provides RCT confirmation of metabolic gains without excess CHF.
Myers et al. (1982) conducted an RCT in Long-term diuretic use with no obvious need (n=77). Active diuretic therapy vs. Placebo was evaluated on Occurrence of congestive heart failure (CHF) or hypertension. Discontinuing unnecessary diuretic therapy (placebo) in the elderly significantly improved metabolic parameters and resulted in only 2 cases of CHF compared to 6 cases with continued therapy.
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