Key result
Serum myoglobin peak concentration correlated significantly with cumulated CK activity (r=0.64, P<0.0001), and levels >100 ng/ml at 48 hours were associated with a 33% mortality rate.
Why the study?
Does serum myoglobin measurement predict infarct size and mortality in patients with acute myocardial infarction?
Population
121 patients admitted to the coronary care unit soon after the onset of symptoms of acute myocardial…
Design
Cohort
Follow-up
3 months
Authors
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SMb kinetics may aid early MI timing assessment; leaves open added prognostic value beyond CK in modern cohorts.
Observational (n=121)
Does serum myoglobin measurement predict infarct size and mortality in patients with acute myocardial infarction?
Effect estimate: r=0.64
p-value: p=< 0.0001
Serum myoglobin measurements early after myocardial infarction correlate with infarct size and can help stratify patient risk for mortality and heart failure.
Chapelle et al. (1982) conducted an observational in Acute myocardial infarction (n=121). Elevated serum myoglobin (SMb) vs. Lower serum myoglobin levels was evaluated on Correlation of SMb peak concentration with cumulated CK activity (r=0.64, p=< 0.0001). Serum myoglobin peak concentration correlated significantly with cumulated CK activity (r=0.64, P<0.0001), and levels >100 ng/ml at 48 hours were associated with a 33% mortality rate.
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