Key result
Concentric left ventricular hypertrophy in COPD patients was associated with lower functional capacity (P=0.045) and decreased grip strength (P=0.006) compared to normal left ventricular geometry.
Why the study?
Chronic obstructive pulmonary disease and abnormalities of left ventricular geometry often coexist, but whether LV geometry is associated with airflow obstruction, functional capacity, and grip strength was unverified.
Is abnormal left ventricular geometry associated with airflow obstruction, functional capacity, and grip strength in COPD patients?
Cross-Sectional (n=37)
Is abnormal left ventricular geometry associated with airflow obstruction, functional capacity, and grip strength in COPD patients?
p-value: p=0.045 for DASI, 0.006 for grip strength
In COPD patients, abnormal left ventricular geometry (concentric remodeling and hypertrophy) is associated with worse airflow limitation, reduced functional capacity, and decreased grip strength.
Concentric LVH may flag higher-risk COPD patients; leaves open whether geometry modification improves outcomes.
PURPOSE: Chronic obstructive pulmonary disease (COPD) and abnormalities of left ventricular (LV) geometry often coexist. This study aimed to verify whether LV geometry is associated with airflow obstruction, functional capacity, and grip strength in COPD patients. METHODS: Thirty-seven COPD patients (GOLD II, III, and IV) were allocated to three groups according to LV geometry as assessed by transthoracic echocardiography: normal (n = 13), concentric LV remodeling (n = 8), and concentric LV hypertrophy (LVH) (n = 16). Lung function was assessed using spirometry. The Duke Activity Status Index (DASI) was used to estimate functional capacity, and grip strength measurement was performed using a hydraulic hand dynamometer. RESULTS: The concentric LVH group presented lower DASI scores (P = .045) and grip strength (P = .006) when compared with the normal group. Correlations analysis showed the following: relative wall thickness negatively correlated with forced expiratory volume in the first second (r = -0.380; P = .025) and DASI score (r = -0.387, P = .018); LV mass index negatively correlated with grip strength (r = -0.363, P = .038). CONCLUSIONS: In COPD patients, LV geometry is associated with airflow limitation, functional capacity, and grip strength. Specifically, concentric LV remodeling is associated with increased airflow limitation and decreased functional capacity whereas increased LV mass is associated with decreased grip strength.
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Heubel et al. (2020) conducted a cross-sectional in Chronic obstructive pulmonary disease (COPD) (n=37). Abnormal left ventricular geometry (concentric LV remodeling and hypertrophy) vs. Normal left ventricular geometry was evaluated on Functional capacity (DASI scores) and grip strength (p=0.045 for DASI, 0.006 for grip strength). Concentric left ventricular hypertrophy in COPD patients was associated with lower functional capacity (P=0.045) and decreased grip strength (P=0.006) compared to normal left ventricular geometry.
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