Key result
Cardiopulmonary bypass significantly increased neutrophil myeloperoxidase and human neutrophil elastase activities in both paediatric and adult patients.
Why the study?
Does cardiopulmonary bypass increase markers of neutrophil activation in paediatric and adult patients?
Observational
Does cardiopulmonary bypass increase markers of neutrophil activation in paediatric and adult patients?
Cardiopulmonary bypass significantly increases neutrophil enzyme activities (MPO and HNE) in both pediatric and adult patients, highlighting the role of neutrophils in CPB-induced systemic inflammation.
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Neutrophil MPO during CPB may signal inflammatory burden; leaves open therapeutic targeting in adults and children.
Larson et al. (1996) conducted an observational in Cardiopulmonary bypass. Cardiopulmonary bypass was evaluated on Neutrophil myeloperoxidase (MPO) and human neutrophil elastase (HNE) activity. Cardiopulmonary bypass significantly increased neutrophil myeloperoxidase and human neutrophil elastase activities in both paediatric and adult patients.
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